Individuals who had obesity and alcohol habits, moreover with excessive alcohol consumption should be aware that those factors will speed up the risk of liver cirrhosis disease or even death risk from those disease.

This warning risk showed at least from 2 prospective studies currently by Dr. Bette Liu from the University of Oxford and colleagues,and Carole L. Hart from the University of Glasgow, Scottland, and colleagues.

Recently the death rate related to cirrhosis of the liver among men and women in the UK recently increased.
As March issue related to this phenomenon from British Medical Journey, Dr. Bette Liu write, “Alcohol is a well established cause of cirrhosis, and, although increases in alcohol consumption over the past 10 years are likely to have contributed to the observed rise in rates, other factors may also have a role. Evidence from prospective studies suggests that excess body weight may result in a substantial increase in the risk of death from liver cirrhosis.”

Based on Dr, Bette Liu and colleagues cohort study which is involved 1,230,662 women who recruited by National Health Service during 1996 to 2001 for the Million Women Study in the Breast Screening Programme, also who where monitored by record linkage to routinely collected data regarding hospital admissions and deaths.

This study aimed to examine the correlation between body mass index (BMI) and liver cirrhosis, including the effect of alcohol consumption and BMI for liver cirrhosis incidence in the UK at middle-aged women.

As the result, the author write, “Excess body weight increases the incidence of liver cirrhosis. In middle aged women in the UK, an estimated 17% of incident or fatal liver cirrhosis is attributable to excess body weight. This compares with an estimated 42% attributable to alcohol.”

Related to alcohol consumption among women the result showed;
- absolute risk for liver cirrhosis per 1000 women at 5 years was 0.8 with the BMI 22.5 to 25 kg/m2 and average alcohol consumption less than 70 g per week,
- absolute risk for liver cirrhosis per 1000 women at 5 years was 1.0 with the BMI
30 kg/m2 or more and average alcohol consumption 150 g or more per week.

Despite several limitation in the study (such as error reportin in BMI and alcohol intake), Dr. Bette conclude incidence of liver cirrhosis risk can reduced by lowering exreme body weight and alcohol consumption as preventive treatment.

Whereas the second study by Carole L. Hart and colleagues through analyse data among 9559 men who enrolled in 2 prospective cohort studies (”Main” and “Collaborative”) found that After adjustment for other confounders, BMI and alcohol intake were strongly associated with liver disease mortality, compared with underweight/normal-weight nondrinkers, drinkers of at least 15 units per week in any BMI category and obese drinkers had raised relative rates for all definitions of liver disease.

Carole L. Hart write, “Raised BMI and alcohol consumption are both related to liver disease, with evidence of a supraadditive interaction between the two. The occurrence of both factors in the same populations should inform health promotion and public health policies.”

With this 2 new findings above, Dr. Christopher D. Byrne, from the University of Southampton, and Dr. S. H. Wild, from the University of Edinburgh, as accompanying editorial, write that prevention is better than cure as increasing incidence and prevalence of liver disease contributed from obesity and alcohol consumption over the time including increasing the prevalence of hepatitis C.

They also recommend further study to improves nonalcoholic fatty liver disease as this condition showed increased too.

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