For older women, risk of osteoporosis and bone fracture already known well. However, by maintaining healthy lifestyle, those risk could be reduces.

On the other side, maintaining lifestyle for older women with diabetes sometime become given unexpected results because they also often prescribed with any kind medications that could worsening the outcomes.
For such cases, some of those patients often prescribed with Thiazolidinedione (TZDs) for type 2 diabetes medication.

According to recent cohort study among older women aged above 65 years who taken this medication, those patients were at risk of osteoporosis, osteoporosis-associated fracture, and hospitalization for congestive heart failure (latest previous study by Henry Ford and other researchers).

Related to osteoporosis, this impact will occur after 1 year of use.
The study looked at a large health system data in Southeast Michigan (9620 women and 9450 men who diagnosed with diabetes and had one or more prescription for an oral diabetes medication) to determine the time-dependent relationship between Thiazolidinedione use and fracture risk, by comparing patients who treated by thizolidinedones and no treated with this medication.

For instance, based on their results, senior author of the study, L. Keoki Williams, MD, MPH, from the Center for Health Services Research and Department of International Medicine at Henry Ford Hospital in Detroit, Michigan, said, “TZDs may put some patients at increased risk for other health issues, and I encourage patients to talk with their physician about other suitable options.”

He added, “If the physician feels the patients should be placed on a TZDs, routine screening for bone loss and prophylactic therapy to prevent bone loss and fractures may also be needed.”

Dr. William noted, “TZDs use was associated with an increased risk for fractures in women, particularly at ages above 65 yr. Clinician should be aware of this association when considering TZD therapy so as to appropriately manage and counsel their patients.”