For older women, risk of osteoporosis and bone fracture already confirmed.
However with maintaining lifestyle those risk could be reduces.

Maintaining lifestyle is not easy especially for older women with had any disease such as diabetes.
Some of this patients prescribed by their physician with Thiazolidinedione (TZDs) medication especially for women who had diabetes mellitus type 2.

Recent cohort study found that for older women especially above 65 years of age who consume with this medication have side effects or risks with osteoporosis, osteoporosis-associated fracture, and congestive heart failure hospitalization (latest previous study by Henry Ford and other researchers).

Related to osteoporosis, this impact will occur after 1 year use.
The study looked at a large health system data in Southeast Michigan (9620 women and 9450 men who diagnosed with diabetes and had one or more prescription for an oral diabetes medication) to determine the time-dependent relationship between Thiazolidinedione use and fracture risk by comparing patients who treated by thizolidinedones and no treated with this medication.

Shortly, based on the result, senior author of the study, L. Keoki Williams, MD, MPH, from the Center for Health Services Research and Department of International Medicine at Henry Ford Hospital in Detroit, Michigan, said, “TZDs may put some patients at increased risk for other health issues, and I encourage patients to talk with their physician about other suitable options.”

He added, “If the physician feels the patients should be placed on a TZDs, routine screening for bone loss and prophylactic therapy to prevent bone loss and fractures may also be needed.”

Dr. William noted, “TZDs use was associated with an increased risk for fractures in women, particularly at ages above 65 yr. Clinician should be aware of this association when considering TZD therapy so as to appropriately manage and counsel their patients.”

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