Patients that have GERD (Gastroesophageal Reflux Disease or Acid Reflux Disease) that had common signs and symptoms such as feeling burning and painful in their eshopagus, digestion problem, difficult in swallowing, some nausea and pain in chest, to much salivation, and other symptoms from injury of eshopagus (such as asthma, extreme cough and some others) often used Proton Pump Inhibitors (PPI) as their treatment and medication/medicine for gerd disease.

But did they know the side effect of long term usage of PPI?

Recent study from long-term usage of Proton Pump Inhibitors will contributes overgrowth of bacterial in small intestinal.
All those bacterial in that condition will producing bloating, diarrhea and other symptoms.

Dr. Luci Lombardo from the Mauriziano U.I Hospital, Torino, Italia, said, “The rationale for using IBS as ‘pathologic’ control stands on the large prevalence of small intestinal bacterial overgrowth in IBS patients and the overlapping of symptoms between two clinical conditions.”

The study involved 450 consecutive patients using glucose hydrogen breath test to see bacterial overgrowth in their small intestinal.

Of 450 patients enrolled in 3 groups:
- 200 gerd patients for median of 3 years treated with PPI
- 200 gerd patients with irritable bowel syndrome for at least 3 years did not PPI
- 50 healthy control who did’t used for at least 10 years not used PPI

The result founded related to bacterial overgrowth in their small intestinal:
- 50% for gerd patients that used PPI
- 24.5% for gerd patients with Irritable bowel syndrome that did not use PPI
- 6% for only healthy control that didn’t used PPI

The lead author concluded while the glucose hydrogen breath test only indirectly detects the condition, it is noninvasive and reproducible, whereas the current standard — aspiration of duodenal - jejunal content for culture — is not.

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