Pregnant women or become pregnant who’s consume Folate supplement is good to prevent neurologic damage for her fetus, and the other benefit for people who take Folate supplement is reducing the risk linked to blindness.

But, for the persons who have ischemic heart disease and take this supplement (vitamin B included Folid Acid) to reduce cardiovascular outcomes, IT WON’T WORK!. Moreover, it’s increase in cancer!

Epidemiologic studies showed that, high serum homocysteine levels are associated with more heart disease, and the folate can lower homocysteine levels.
Hoping for this data, lowering homocysteine level would lower the risk of heart disease. But IT DIDN’T TURN OUT THAT WAY!

The recent study for this case showed significantly increase in cancer incidence, cancer mortality, and all-cause mortality.

Marta Ebbing, MD., led of this study, from Haukeland University Hospital in Bergen, Norway said, “This result, although in need of confirmation, suggest that there is a need for safety monitoring because there is now widespread folic acid fortification of foods and increasing use of folic acid in dietary supplements.”

But, from other accompanying editorial, Betina F. Drake, PhD, MPH and Graham Colditz, MD, DrPH, both from the Washington University School of Medicine in St Louis, Missouri, pointed out that folate supplementation used in the study was conducted in indvidual with heart disease and was of limited duration.

As reference, cancer incidence and mortality in this study was mainly driven by an increase in lung cancer incidence. And, 94% of the subjects who developed lung cancer were either current or former smokers.

Folate is a water-soluble B vitamin that occurs naturally in food. Folid acid is the synthetic form of folate that is found in supplements and added to fortified foods.

The natural source of folate are leafy green vegetables (ex. spinach and turnip greens), fruits (ex. citrus fruits and juices0, dried beans and pears.

FDA published regulation requiring the addition of folic acid to enriched breads, cereals, flours, corn meals, pastas, rice, and other grain products in 1996.
Whole this products now very popular consumption in the US as “diet food”.

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