Healthcare
No matter how we manage our health, efficacy, risks and costing are top concernsCombination of Clopidogrel and Aspirin worsens outcomes in long-term effects
While some suggestions said that adding Clopidogrel to Aspirin could help patients prevents recurrent attack, actually however, this combination this combination has no benefit at all compared to the use of aspirin alone in patients with subcortical stroke.
In fact, combination of these drugs for long-term effect even greater risk of all-cause mortality, major bleeding, and non-vascular mortality.
This conclusion presented in the International Stroke Conference (ISC) 2012, held on February 3, 2012.
According to lead of study author, Oscar Benavente, MD, professor and research director of Cerebrovascular Health and Stroke of the University of British Columbia, Canada, of 3029 subjects involved in the Secondari Prevention of Small Subcortial Strokes (SPS3) study, after followed-up for 3.5 years, both of groups (Aspirin+Placebo group and Aspirin+Clopidogrel group) have similar incidents of recurrent ischemic and hemorrhagic strokes.
In fact, according to the findings, all-cause mortality in Aspirin+Clopidogrel group showed higher than Aspirin+Placebo group (113 vs. 77 cases), higher in vascular death (26 vs. 19 cases), higher in vascular deaths (19 vs. 6 cases), and higher in non-vascular deaths (41 vs. 32 cases).
This includes higher major hemorrhages (105 vs. 56 cases).
Since this findings as an effects of long-term effects of Aspirin+Clopidogrel, further studies still on going related to short-term effects with this drug combination.
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Edgar said on Sunday, March 25, 2012, 11:13
It is a Transient Ischemic Attack. Sometimes referred to as a minor stroke. It means that a blood vessel in an area of the brain was (partially or completely) blocked for a time. These blockages are, as the name implies, temporary, and often resolve themselves within a day or two. The symptoms vary widely depending on the size and location of the vessel and the area of the brain affected. Since this may be your second bout with it, you should definitely see your neurologist. Something should be done to prevent further attacks. These minor strokes (if that is what this second incident was) may be a warning. Do not wait to get it checked out. The next one could cause permanent damage. The aspirin works as a blood thinner to help prevent blood clots, but, by itself, may not resolve any blood clots. Keep taking it until you meet with your doctor and he advises you differently. Just as a note: 4 baby aspirins = 324 mg. 1 regular aspirin = 325 mg. If you take the baby aspirin one every 4 hours or so throughout the day it may maintain a therapeutic level better than one regular aspirin once a day. See your doctor!!!