Healthcare
No matter how we manage our health, efficacy, risks and costing are top concernsProton pump inhibitors therapy (PPI) increase 3-fold of community-acquired pneumonia risk
Proton pump inhibitors are useful drugs to inhibit gastric acid secretion.
While previous studies has indicated the risk of community-acquired pneumonia (CAP), a new study giving more evidences that these class of drug can increase the risk of CAP by 3-fold.
Therefore, patients who use these drugs should be in right criteria (such as for peptic ulcers, gastroesophageal reflux disease, and esophagitis) and been evaluated that the benefits outweigh the risk.
The increasing risk of CAP in the current findings based on population and case-control study that found 12 of 430 adults with CAP have used PPI (2.8%), compared with 16 non-user who have CAP from 1,720 adults matched controls (0.9%).
Also, the incidences of admitted to the intensive care unit (ICU) were more than 30% in CAP patients with PPI use (4 of 12 CAP patients), compared with 7% for CAP non-PPI’s user.
According to the findings that reported in the European Respiratory Journal on April 8, 2011, “Neither gastrointestinal nor oropharyngeal bacteria were more present in patients using a PPI compared to patients not using a PPI.”
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