Healthcare
No matter how we manage our health, efficacy, risks and costing are top concernsClinicians should be careful when prescribed proton pump inhibitor (PPI) drugs because the side effects of any fractures risk
The proton pump inhibitor (PPI) drug is one of popular drug to reduce gastric acid secretion.
Together with histamine 2 receptor antagonist (H2RA) drugs, both of them are often used in patients for long term period to treat the disorders.
In addition, some disorders are also often use these drugs.
However, until today there is no clear information regarding to their effect to bone health.
By using database from MEDLINE (PubMed), Cochrane Library, and EMBASE, the researchers found that patients who take PPIs should be known that there is potential risk of any fractures.
According to the study authors, Chun-Sick Eom, MD, MPH, from Seoul National University, Republic of Korea, and colleagues, compared with H2RA, PPIs had significant any fracture risk.
Moreover, according to the findings that reported in Annals of Family Medicine archive for May/June issue, the fracture risk included hip fracture and vertebral fracture can elevated with long term use of PPIs. At least, in the vertebral fracture risk, the use of PPI drug produce higher risk by 54% compared to H2RA drug.
The study authors write, “We found possible evidence linking PPI use to an increased risk of fracture, but no association between H2RA use and fracture risk.”
Therefore, the study authors caution the clinicians during prescribed the medicine, moreover to “the patients that at risk of fracture because of age or other factors,” and they recommended that “drug doses be chosen thoughfully with consideration of what is necessary to achieve desired therapeutic goals.”
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