Men who want to reduce their prostate cancer risk shouldn’t bother popping antioxidant vitamins and supplements, according to two of the largest trials ever conducted on vitamins and cancer prevention.
Vitamin E, alone, with selenium or in combination with vitamin C did not prevent prostate cancer.

Vitamin E, alone, with selenium or in combination with vitamin C did not prevent prostate cancer.

The studies, published this week in the Journal of the American Medical Association, show that vitamin C, vitamin E, and selenium won’t ward off prostate cancer — or other types of the disease — in men.

In one study, 35,533 cancer-free men in their 50s or older took selenium and vitamin E alone or in combination. Several years later, they had the same risk of developing the disease as men who took a placebo. In a second study of 14,641 men — some of whom may have had early-stage prostate cancer — a combination of vitamin E and vitamin C didn’t prevent prostate cancer, or any other type of cancer.

“It looks like these particular antioxidants are not effective,” says Howard Soule, Ph.D., chief scientific officer of the Prostate Cancer Foundation in Santa Monica, California, who was not involved in either study.

According to the American Cancer Society, 1 in 6 men will get prostate cancer in his lifetime, and 1 in 35 will die of the disease. The ACS estimates that 28,660 U.S. men will die of prostate cancer in 2008, accounting for roughly 10 percent of all cancer-related deaths in men.

Vitamins seemed promising in the 1990s, after one study found that men who took selenium supplements had a 65 percent lower risk of prostate cancer, and another found that vitamin E cut risk by 35 percent. But those findings were from trials not specifically designed to examine prostate cancer, or trials examining men who were taking vitamins for other reasons.

So researchers launched the two new studies: the Selenium and Vitamin E Cancer Prevention Trial, or SELECT, led by Scott M. Lippman, M.D., of the University of Texas M.D. Anderson Cancer Center, and Eric A. Klein, M.D., of the Cleveland Clinic Lerner College of Medicine; and the Physicians’ Health Study II Randomized Controlled Trial (of vitamins C and E), led by J. Michael Gaziano, M.D., of Brigham and Women’s Hospital and VA Boston Healthcare System.

The Physicians’ Health Study followed participants for 10 years, while SELECT — the largest clinical trial ever run of chemoprevention for cancer — was halted early when researchers found the supplements provided no benefit.

Durado Brooks, M.D., director of prostate cancer for the American Cancer Society, called the findings “disappointing,” noting that for many years men have been taking the vitamins in the hopes that they would be protective.

“There was a lot of hope in the community that vitamin E, selenium, something was going to pan out,” says Brooks, who was not involved in either study. “Right now, we don’t have any agents that we can point to and say that these agents can clearly and unambiguously and safely decrease your risk of developing prostate cancer.”

Although some experts might argue that supplements could be effective in different doses or combinations than those used in the study, “it’s doubtful that the results would be any different,” says SELECT study author Klein.

Neither study showed harm from taking the supplements, notes Gaziano, who participated in both studies. But this doesn’t mean people should keep doing so, he warns.

“I think that the potential downside of taking something that’s not proven to be effective is that there are only so many things that we can get our patients to do,” Gaziano says. “If we think we’re getting the benefit from the pill, we may be less inclined to do the other things that may be more difficult but we know are going to be more beneficial.”

And what are those beneficial things? Klein notes that in the Prostate Cancer Prevention Trial, the drug finasteride reduced a man’s chances of developing prostate cancer by 25 percent.

The drug tested in that trial is the same medication in the anti-baldness drug Propecia, but at a higher dose. Klein suggests that men concerned about their prostate cancer risk talk to their doctor about taking finasteride.

There is also some evidence — though no firm proof — that exercising, quitting smoking, maintaining a healthy weight, and eating less fat could help prevent prostate cancer or slow the progression of the disease. Following a Mediterranean-style diet, which includes plenty of fruits and vegetables, healthy oils from fish and nuts, and moderate amounts of alcohol, may also be beneficial, Gaziano says.

Even pomegranate juice and broccoli may help, and they can’t hurt, advises Soule. “A lot of things that appear to have a scientific rationale for chemoprevention may also make you healthy,” he says.

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