Healthcare

The US Food and Drug Administration in July 29, 2010, announced that physician should advise women who use Evaminst (Ther-Rx; an estradiol transdermal spray, a prescribed to reduce hot flashes in menopausal women) to prevent children from coming into contact with their medicated skin, to avoid possible adverse event such as enlarge breast for boys and premature puberty for girls. The adverse event also may happen to pets when exposed with this drug.

According to the FDA alert, those receiving the drug spray it on the inside of their forearm between the wrist and elbow, if patients can’t prevent a child from coming into contact with a patch of sprayed skin, they should wear a long-sleeved garment. If children are exposed to the drug through skin contact, they should be washed with soap and water as soon as possible.

8 cases of children ages 3 to 5 years reported and received by FDA who were accidentally exposed to the drug. They (in the girls) experienced with nipple swelling and breast development, and experienced with breast enlargement (in the boys).
These adverse events occurred several weeks to months after an adult began using the spray. With some cases, the problems resolved themselves once the adult stopped using the drug or took steps to prevent the children from touching medicated skin.

Due to drug exposed to the pets, the FDA has received report of mammary and nipple enlargement, vulvar swelling, and liver failure occurring in 1 female dog.
Another one female dog experienced with vaginal prolapse and elevated estrogen levels.
The agency stated in the consumer health bulletin, “small pets may be especially sensitive to the estrogen in Evamist.”