One of topical treatment for genital warts removal products approved by FDA is Imiquimod 5% cream.
Several randomized clinical trials showed this cream categorized safe and works fine (about 50%) even the recurrent infection ‘seem moderate’ (19% after 3 month and 23% after 6 month).

Some clinician also suggest combination with surgery treatment to reduce the risk of reccurrence warts or if the cream works insufficient.

However from the trial also found dominant adverse effect related to local inflammation and others adverse effects such as pain, linear abrasion or punctate that may reached papillary dermis, burning sensation, irritation, tenderness, and ulcer in genital are.
All this happened because the Imiquimod 5% cream had side effect to the immune system problem.

Therefore patient who find their warts size become grow should stop using this cream and immediately contact their doctor.
This cream also should not applied for the women during pregnancy.