Recent study from Georgetown University, Washington, DC, reported that Prostate Cancer Therapy with profound hypogonadism due to Androgen Deprivation Therapy may results in complications of;

- Sexual dysfunction
- Poor quality of live
- Vasomotor symptoms
- Altered cognition

Androgen deprivation therapy (ADT) is generally employed in the treatment of locally advance and metastatic Prostate cancer.
Although it’s use an adjuvant therapy has resulted in improved survival in some patients, ADT has negative impact other than above result.

Other complication related to Androgen Deprivation Therapy are;

- Osteoporosis
- Gynecomastia
- Adverse body composition

Since estrogen is associated with cardiovascular risk, phytoestrogens are being increasingly evaluated as a potential treatment for these adverse effect.

The researcher evaluated the effects of high dose isoplavone on the aforementioned consequences of androgen deprivation therapy.

The research involving 33 men undergoing ADT for prostate cancer were enrolled in this randomized, double-blind, placebo controlled, in 12 week.

The result, men in the isoplavone group had a higher-baseline prevalence of hot flashes and poor intercourse satisfaction compare to those on placebo.

Hot flashes is the most common vasomotor symptoms.
Vasomotor symptoms are viewed largely as a symptom affecting quality of live and are the leading reason women seek menopause-related health care.
Recently vasomotor symptoms have also been found to be linked with a less favorable cardiovascular risk profile and atherosclerosis.

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